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Molecular mechanisms of isoniazid: a drug at the front line of tuberculosis control
1MRC Tuberculosis and Related Infections Unit, RPMS, Hammersmith Hospital, London, UK.
Trends in Microbiology
|June 1, 1993
Abstract:
The resurgence of tuberculosis and emergence of multidrug-resistant isolates has focused attention on the need for an improved understanding of molecular aspects of the disease, and for elucidation of the factors responsible for drug action and resistance. Recent research has probed the mechanism of action of isoniazid (INH), a key drug in the chemotherapy of tuberculosis.