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Novel targets and catalytic activities of bacterial protein toxins
G Schiavo1, B Poulain, F Benfenati
1Dipartimento di Scienze Biomediche, Università di Padova, Italy.
Trends in Microbiology
|August 1, 1993
Abstract:
Among bacterial protein toxins with intracellular targets, tetanus and botulinum toxins form a group with unique properties. They are absolutely neurospecific and act in the cytosol of neurons. Recent evidence indicates that they are zinc proteases specific for proteins of the neuroexocytosis apparatus.