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Transient ischemic attacks associated with amfepramone therapy: a case report
Abstract:
A 33-year-old man was prescribed amfepramone 75 mg o.i.d. for the treatment of obesity. One week after onset of therapy, he suddenly became agitated and aphasic for several h. A CT scan of the brain was normal. Amfepramone was discontinued. Three days later, there was a second period of agitation and aphasia with a discrete right hemiparesis lasting 12 h. A repeat CT scan and a MRI of the brain were normal. On EEG and brain mapping, alpha-activity was absent over the left hemisphere and a left fronto-temporal delta-focus was found. A Tc-99m HMPAO brain SPECT showed a severe hypoperfusion of the left hemisphere. The next day, the neurological examination was completely normal. Two weeks later, EEG and SPECT had completely normalized. Transient ischemic attacks due to vasospasm were considered to be the most probable clinical diagnosis.
Insights
A patient experienced transient neurological symptoms, including agitation and aphasia, after starting amfepramone for obesity. These episodes, possibly transient ischemic attacks, resolved after medication cessation and diagnostic imaging revealed temporary brain hypoperfusion.
Area of Science:
- Neurology
- Pharmacology
Background:
- Obesity treatment often involves pharmacotherapy.
- Amfepramone is an appetite suppressant used for weight management.