Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modelling the dynamic ventilatory response to hypoxia in normal subjects

T P Kirby1, P K Wraith, S C De Cort

  • 1Rayne Laboratory, Unit of Respiratory Medicine, University of Edinburgh, Scotland, U.K.

Journal of Theoretical Biology
|January 21, 1994
PubMed
Summary

We created a mathematical model for the dynamic ventilatory response to hypoxia during exercise. This model accurately describes how breathing changes with oxygen saturation, using parallel equations with fast and slow components.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Commentary on: Inspiratory Muscle Training, with or without Pulmonary Rehabilitation, for COPD: A Critical Appraisal of a Cochrane Review.

Journal of the Association of Chartered Physiotherapists in Respiratory Care·2025
Same author

Constraint-induced movement therapy following stroke: a commentary.

British journal of neuroscience nursing·2025
Same author

Health and social care: The link between social care deficiencies and health care pressures.

British journal of health care management·2024
Same author

Calcium supplementation for the prevention of hypertension: a synthesis of existing evidence and implications for practise.

British journal of cardiac nursing·2024
Same author

The impacts of Covid-19 on perinatal mental health - Part 2.

The practising midwife·2024
Same author

Prevalence, severity and preventability of prehospital patient safety incidents.

Journal of paramedic practice : the clinical monthly for emergency care professionals·2024

Area of Science:

  • Physiology
  • Mathematical Modeling
  • Respiratory Control

Background:

  • Hypoxia significantly impacts ventilatory control.
  • Understanding the dynamic ventilatory response to hypoxia is crucial for physiological studies.
  • Previous models have not fully captured the complexities of this response during exercise.

Purpose of the Study:

  • To develop and validate a mathematical model for the dynamic ventilatory response to hypoxia.
  • To characterize the ventilatory response to both transient and sustained hypoxic stimuli during moderate exercise.
  • To identify key parameters influencing the ventilatory response to hypoxia.

Main Methods:

  • Measured ventilatory response in ten healthy subjects during moderate exercise (VO2 ~0.96 L/min).

Related Experiment Videos

  • Applied transient (2-3 breaths N2) and 3-min step-change hypoxic stimuli.
  • Developed a mathematical model using two parallel linear differential equations with fast (<3s) and slow time constants.
  • Incorporated non-linear terms: saturation effect (Michaelis-Menten) and potentiation/inhibition.

    • Main Results:

    • A model with two parallel linear differential equations adequately described the ventilatory response in all subjects.
    • The model included a fast (<3s) and a slow time constant.
    • Non-linearities included a saturating effect on the slow component and potentiation/inhibition influenced by the fast component's output.
    • Significant inter-subject variability was observed in the gain of the fast time constant equation.

    Conclusions:

    • The developed mathematical model effectively captures the dynamic ventilatory response to hypoxia during exercise.
    • The model's structure, featuring parallel fast and slow components with non-linear interactions, provides insights into respiratory control mechanisms.
    • The findings suggest similarities between human and animal models of peripheral chemoreceptor-mediated hypoxic ventilatory response.