[Allergic reactions of the respiratory tract]

Allergic rhinoconjunctivitis and allergic asthma bronchiale are immunologically mediated diseases of the respiratory tract. Dependent on the allergen, they occur seasonally or perennially. Allergens can cause a specific reaction of the immune system, mediated by IgE-antibodies in individuals with a genetic predisposition. Different mediators are released from mast cells, and complex immunopathological mechanisms lead to inflammatory changes of the mucosa. A significant increase of allergies has been observed in the last decades. Indoor and outdoor allergens can be differentiated. Mites and animal dander are the most important indoor allergens. The pollens of birch, alder, hazel, different grasses and mugwort are the most important outdoor allergens. For diagnostic purposes skin tests, laboratory analyses and provocation tests are used. The best therapy is elimination of the offending allergen. As pharmacological agents histamine-receptor antagonists, topical corticosteroids and topical cromoglycate are currently used. Immune therapy is the most specific form of treatment.