Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ventricular perspective on efficiency

H Suga1, Y Goto, O Kawaguchi

  • 1Department of Physiology II, Okayama University Medical School, Japan.

Basic Research in Cardiology
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Formation and evolution of carbonaceous asteroid Ryugu: Direct evidence from returned samples.

Science (New York, N.Y.)·2022
Same author

Serum-Stable and Selective Backbone-N-Methylated Cyclic Peptides That Inhibit Prokaryotic Glycolytic Mutases.

ACS chemical biology·2022
Same author

Extranodal natural killer/T-cell lymphoma, nasal type with CCR3 and CXCR3 expression.

Clinical and experimental dermatology·2020
Same author

Concurrence of polyarteritis nodosa and multiple sclerosis.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Population Structure of the Fusarium graminearum Species Complex from a Single Japanese Wheat Field Sampled in Two Consecutive Years.

Plant disease·2019
Same author

Development of PCR Primers to Identify Fusarium oxysporum f. sp. fragariae.

Plant disease·2019
Same journal

Molecular mechanisms of coronary microembolization-induced MINOCA.

Basic research in cardiology·2026
Same journal

Protection against postoperative atrial fibrillation via antiplatelet aggregation induced by remote ischemic preconditioning during off-pump coronary artery bypass grafting.

Basic research in cardiology·2026
Same journal

Peroxisomal catalase and plasmalogen biosynthesis protect from oxidative stress in Barth syndrome cardiomyopathy.

Basic research in cardiology·2026
Same journal

Bicuspid aortic valve stenosis is characterized by increased angiogenesis, inflammation, and a higher valvular-to-systemic calcification ratio than tricuspid aortic valve stenosis.

Basic research in cardiology·2026
Same journal

Myofilament-level effects of aficamten increase diastolic chamber volumes and maintain cardiac output through preserved length-dependent force generation in healthy rat and canine myocardium.

Basic research in cardiology·2026
Same journal

Functional rejuvenation of endothelial cell aging by transient reprogramming.

Basic research in cardiology·2026
See all related articles

We developed a method to measure heart mechanical energy (PVA) and found it directly relates to oxygen consumption. This contractile efficiency is stable at 40%, offering insights into cardiac energy conversion.

Area of Science:

  • Cardiology
  • Physiology
  • Biophysics

Background:

  • Cardiac mechanical work efficiency is conventionally defined.
  • Quantifying total mechanical energy from ventricular contraction is crucial.

Purpose of the Study:

  • To propose and validate a method for quantifying total mechanical energy generated by ventricular contraction.
  • To investigate the relationship between this mechanical energy and myocardial oxygen consumption.

Main Methods:

  • Utilizing excised, cross-circulated dog heart preparations.
  • Measuring left ventricular pressure-volume loops to determine systolic pressure-volume area (PVA).
  • Correlating PVA with oxygen consumption (VO2) under varying loading conditions and contractility states (Emax).

Related Experiment Videos

Main Results:

  • A linear relationship was observed between PVA and VO2 in a stable contractile state.
  • Enhanced contractility (increased Emax) elevated the VO2-PVA relationship proportionally.
  • Average contractile efficiency (PVA-dependent VO2 to PVA conversion) was 40%, independent of inotropic interventions.

Conclusions:

  • Systolic pressure-volume area (PVA) is a reliable index of total mechanical energy output.
  • Cardiac contractile efficiency is a stable parameter, distinct from the variable energetic costs of force generation.