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Atherosclerosis and glycation

C A Colaco¹, B J Roser

¹Quadrant Research Foundation, Cambridge, UK.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology

|February 1, 1994

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Glycated LDL, not oxidized LDL, may be the primary cause of atherosclerosis. This finding could explain the link between diabetes, sugar intake, and cardiovascular disease.

Area of Science:

Cardiovascular Science
Metabolic Disease Research

Background:

Atherosclerosis is a leading cause of death globally.
Oxidized low-density lipoprotein (LDL) is implicated in atherosclerotic plaque development, but its in vivo form is unclear.

Purpose of the Study:

To investigate whether glycated LDL exhibits characteristics of oxidized LDL in vivo.
To propose glycated LDL as a potential source of oxidized LDL in atherosclerosis.

Main Methods:

Comparative analysis of glycated LDL and oxidized LDL properties.
Hypothesizing the role of apolipoprotein E in glycated LDL clearance.

Main Results:

Glycated LDL shares key pathogenic features with oxidized LDL.
Increased uptake and impaired degradation by macrophages observed for glycated LDL.

Related Experiment Videos

Stimulation of monocyte chemotaxis, cytokine secretion, and platelet aggregation by glycated LDL.

Conclusions:

Glycated LDL may be the in vivo equivalent of 'oxidized LDL', driving atherosclerosis.
The hypothesis explains the high incidence of atherosclerosis in diabetics and links sugar intake to the disease.