Related Experiment Video
Updated: Aug 12, 2026
07:27
Implantation of Total Artificial Heart in Congenital Heart Disease
Published on: July 18, 2014
[The patient after heart transplantation]
M Gebauerová1, R Jandová, I Málek
1Klinika kardiologie, Institut klinické a experimentální medicíny, Praha, Ceská republika.
Cor Et Vasa
|January 1, 1993
Summary
Heart transplantation outcomes improved significantly between 1984-1993, with reduced early mortality. Despite side effects like hypertension and obesity, the procedure substantially prolongs life and improves quality of life for recipients.
Area of Science:
- Cardiology
- Transplantation Medicine
- Immunosuppression
Background:
- Heart transplantation is a life-saving procedure for end-stage heart failure.
- Long-term outcomes and complications require ongoing evaluation.
Purpose of the Study:
- To analyze the outcomes and complications of the first 100 heart transplantations at the Institute for Clinical and Experimental Medicine in Prague.
- To assess changes in mortality rates and identify common causes of death and post-transplant morbidities.
Main Methods:
- Retrospective analysis of data from the first 100 heart transplant recipients.
- Data collection on patient survival, causes of death, and post-transplantation complications including hypertension, renal impairment, obesity, and ulcers.
Main Results:
- Overall survival was 57% among the first 100 patients.
- Early mortality (within 30 days) decreased from 37% (1984-88) to 17% (1989-93).
- Common causes of death included graft failure, infection, and accelerated coronary atherosclerosis; significant morbidities included hypertension (60% at 5 years), renal impairment (70% at 1 year), obesity (45% at 1 year), and ulcers (16%).
Conclusions:
- Heart transplantation has become an established and effective treatment, with significant improvements in early outcomes.
- While immunosuppressive therapy leads to notable side effects, the procedure offers substantial life prolongation and improved quality of life for patients.
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