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Migraine: possible role of platelet insensitivity to prostaglandin E1 (PGE1)
F Cerneca1, S de Luyk, O Radillo
1Clinical Pathology Laboratory Haemostasis Service, Pediatric Hospital Burlo Garofolo, Trieste, Italy.
Functional Neurology
|November 1, 1993
Abstract:
Platelet aggregation inhibition, induced by prostaglandin E1 (PGE1), was evaluated in 38 patients affected by migraine. Our data indicate a complete insensitivity to PGE1 in these subjects. The insensitivity to PGE1 leads to decreased cyclic-AMP (cAMP) levels, determining an imbalance in the inhibitory mechanism. From this observation we can suppose that the decreased affinity of PGE1-receptors, causing decreased cAMP levels, may be involved in pathogenesis of migraine.