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Synthesis of trehazolin beta-anomer
1Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
The Journal of Antibiotics
|February 1, 1994
Abstract:
Synthesis of trehazolin beta-anomer (3) from a D-glucose derived azido alcohol (4), was accomplished. 2-Chloro-1-methylpyridinium iodide was used in place of 2-chloro-3-ethylbenzoxazolium tetrafluoroborate as a means of preventing concomitant anomerization. Evaluation of compound (3) reveals that the stereochemistry of the anomeric position is significant for generation of inhibitory activities towards trehalases.