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Navelbine and the anthrapyrazoles
Hematology/Oncology Clinics of North America
|February 1, 1994
Abstract:
This article reviews the preclinical and early clinical development of navelbine and the anthrapyrazoles. The differences in structure from the "parent" compounds that may confer clinical advantages are discussed. The preclinical data, clinical pharmacology, and Phase I trials are reviewed. Further development of these drugs in Phase II trials and comparative studies is also discussed.