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Oocyte donation: comparison between recipients from different age groups

C Flamigni1, A Borini, F Violini

  • 1Department of Obstetrics and Gynaecology, University of Bologna, Italy.

Human Reproduction (Oxford, England)
|December 1, 1993
PubMed
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Oocyte donation success rates decrease significantly with recipient age. Older women experience lower pregnancy and implantation rates, indicating uterine age impacts outcomes.

Area of Science:

  • Reproductive Medicine
  • Infertility Research
  • Gestation Studies

Background:

  • Oocyte donation is a key assisted reproductive technology (ART) for infertility.
  • Recipient age is a critical factor influencing ART success rates.
  • Uterine receptivity may decline with advancing maternal age.

Purpose of the Study:

  • To investigate the impact of recipient age on oocyte donation outcomes.
  • To compare pregnancy and implantation rates across different recipient age groups.
  • To assess the influence of uterine age on oocyte donation success.

Main Methods:

  • Retrospective analysis of 87 patients undergoing 141 oocyte donation cycles.
  • Standardized hormonal replacement therapy and in-vitro fertilization (IVF) protocols.

Related Experiment Videos

  • Recipients categorized into four age groups (21-35, 36-40, 41-49, 50-61 years).
  • Oocyte donors aged 21-35 years.

    • Main Results:

    • Pregnancy rates: 45% (21-35 yrs) vs. 23% (41-49 yrs).
    • Implantation rates: 23% (21-35 yrs) vs. 10% (41-49 yrs).
    • Younger recipients (21-35 yrs) showed significantly higher success rates compared to older groups.
    • Success rates in young recipients mirrored those of oocyte donors.

    Conclusions:

    • Recipient age significantly affects oocyte donation success.
    • Advanced uterine age is associated with reduced pregnancy and implantation rates.
    • Oocyte donation outcomes are optimized when recipient uterine age is younger.