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[On the mode of action of antirheumatic drugs (author's transl)]
Abstract:
Since the etiology of rheumatoid arthritis presently is mostly unknown, the therapeutical efforts are focussed on attempts to influence the pathogeneic events occurring in this disease. Among the discussed pathogenic mechanisms aberration of immunereactions seem to play an important role. The drugs mainly used for basical treatment of rheumatoid arthritis are cytostatics, D-penicillamine, gold salts and chloroquine. The clinical experiences with these drugs and their mode of action are reviewed.
Insights
Rheumatoid arthritis treatment focuses on managing disease progression due to unknown causes. Current therapies like cytostatics, D-penicillamine, gold salts, and chloroquine target immune system aberrations and their pathogenic events.
Area of Science:
- Immunology
- Pharmacology
- Rheumatology
Context:
- The exact cause of rheumatoid arthritis remains largely unknown.
- Therapeutic strategies aim to modulate pathogenic mechanisms.
- Immune system dysregulation is a key factor in rheumatoid arthritis pathogenesis.
Purpose:
- To review current therapeutic approaches for rheumatoid arthritis.
- To discuss the clinical experiences and mechanisms of action for key drugs.
- To highlight the role of immunomodulation in rheumatoid arthritis management.
Summary:
- This review examines the primary treatments for rheumatoid arthritis, including cytostatics, D-penicillamine, gold salts, and chloroquine.
- It details the clinical efficacy and proposed modes of action for these disease-modifying antirheumatic drugs (DMARDs).
- The focus is on influencing pathogenic events, particularly immune system aberrations, in rheumatoid arthritis.
Impact:
- Provides an overview of established rheumatoid arthritis treatments.
- Informs clinicians about the practical use and mechanisms of common antirheumatic drugs.
- Contributes to understanding the management of immune-mediated inflammatory diseases.