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Updated: Aug 17, 2026

Multicolor Flow Cytometry Analyses of Cellular Immune Response in Rhesus Macaques
Published on: April 22, 2010
Evolution of the human immunodeficiency virus type 2 envelope gene in preimmunized and persistently infected rhesus
M H Bäyon-Auboyer1, F D Boussin, G Vogt
1Laboratoire de Neuropathologie Expérimentale et Neurovirologie, Commissariat à l'Energie Atomique, Fontenay-aux-Roses, France.
Abstract:
The V3 and V4 domains of human immunodeficiency virus type 2 (HIV-2) env genes from 14 rhesus macaques experimentally infected by HIV-2 SBL6669/H5 were sequenced. No variation was observed in viral sequences from sera and from uncultured peripheral blood mononuclear cells during primary infection. The first mutations were detected 17 months after infection; they mainly concerned the region between the V3 and V4 domains and not those domains themselves, which are known to be hypervariable, suggesting that variation of V3 is a late event of HIV infection.
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