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Updated: Aug 11, 2026
11:02
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Human cancer vaccines
J Sinkovics1, J Horvath, M Szabo-Szabari
1Cancer Institute, St. Joseph's Hospital, Tampa, Florida 33607.
Leukemia
|April 1, 1994
Summary
Generating tumor-reactive immune cells is possible by modifying antigen expression and expanding lymphocytes. Active immunization can induce tumor rejection, eliminating micrometastases and potentially causing remission in advanced cancers.
Area of Science:
- Immunology
- Oncology
- Cellular Biology
Background:
- T cells recognize antigens presented by self-MHC molecules.
- This mechanism allows for the generation of lymphocytes reactive to tumor cells.
Purpose of the Study:
- To explore methods for generating and expanding tumor-reactive lymphocyte populations.
- To investigate the potential of active immunization to induce anti-tumor immune responses in humans.
Main Methods:
- Modification and intensification of tumor antigenic expression.
- Expansion of reactive lymphocyte populations.
- Active immunization protocols in tumor-bearing human hosts.
Main Results:
- Successful generation of auto-tumor reactive lymphocyte populations.
- Induction of immune reactions with tumor rejection capabilities.
- Elimination of micrometastases and induction of partial or complete remission in gross metastases.
Conclusions:
- Active immunization strategies can harness T cell-mediated immunity for cancer treatment.
- Enhancing tumor antigen presentation and expanding reactive lymphocytes are key to effective immunotherapy.
- This approach shows promise for controlling both minimal and established tumor burdens.
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