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Phencyclidine reduces inherited neocortical spindling in DBA/2J mice
A Capasso1, A Di Giannuario, A Loizzo
1School of Pharmacy, University of Salerno, Italy.
Life Sciences
|January 1, 1994
Abstract:
The role of phencyclidine (PCP) in the control of the spike-and-wave spindling episodes (S&W) which can be spontaneously recorded in the electrocorticogram (ECoG) of DBA/2J mice was investigated. PCP (0.1-0.5-1.0-5.0 mg/kg/i.p.) dose dependently reduced both S&W number and duration of DBA/2J mice. PCP reduction is significant 30-60 min after drug administration and lasts for the whole duration of the recording period (240 min). These results suggest that PCP may play an important regulatory role on brain excitability.