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[Flocculation of NPH insulin]

J Playán1, J Acha, H Navarro

  • 1Servicio de Endocrinología, Hospital Miguel Servet, Zaragoza.

Revista Clinica Espanola
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

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Human NPH insulin flocculation can worsen diabetes control, leading to diabetic ketoacidosis. Patients should inspect insulin vials for flocculation before each injection to ensure metabolic stability.

Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • Human insulins are increasingly replacing animal insulins due to lower antigenicity.
  • Human Neutral Protamine Hagedorn (NPH) insulin is a common treatment for diabetes.
  • Flocculation, a physical change in insulin formulation, is a known issue with NPH insulin.

Observation:

  • This study observed four diabetic patients experiencing worsened metabolic control after using flocculated human NPH insulin.
  • Two patients developed diabetic ketoacidosis without other identifiable causes, correlating with the use of flocculated insulin.

Findings:

  • Flocculation of human NPH insulin can significantly impair glycemic control.
  • Factors contributing to flocculation include temperature fluctuations, transport, and prolonged vial opening for multiple doses.

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Implications:

  • Healthcare providers and patients need to be aware of NPH insulin flocculation.
  • Diabetics should visually inspect insulin vials for signs of flocculation before administration.
  • Early detection of flocculation can prevent adverse metabolic events and improve diabetes management.