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Sinusitis in bone marrow transplantation

S Yee1, S J Stern, H G Hearnsberger

  • 1Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock 72205-7199.

Southern Medical Journal
|April 1, 1994
PubMed
Summary
This summary is machine-generated.

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Bone marrow transplants can cause fever, often of unknown origin. Sinusitis is rarely diagnosed despite being a potential cause, highlighting a missed diagnostic opportunity in transplant patients.

Area of Science:

  • Hematology
  • Transplant Medicine
  • Infectious Diseases

Background:

  • Bone marrow transplantation is a vital curative treatment for hematologic conditions and certain solid tumors.
  • Immunosuppression post-transplant increases the risk of infections.
  • Fever is a common complication following bone marrow transplantation.

Observation:

  • A retrospective study evaluated fever causes in bone marrow transplant patients.
  • 68% of patients experienced fever post-transplant.
  • 59% of post-transplant fevers were of unknown origin.

Findings:

  • Sinusitis was diagnosed in only 1% of febrile patients.
  • Sinusitis was infrequently suspected or included in the differential diagnosis for fever.
  • A significant percentage of post-transplant fever remains unexplained.

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Implications:

  • Underdiagnosis of sinusitis in bone marrow transplant recipients is likely.
  • Routine evaluation for sinusitis should be considered in febrile transplant patients.
  • Improving fever workup can enhance patient outcomes and reduce healthcare costs.