Effective dose in cattle of toxic alkaloids from tall larkspur (Delphinium barbeyi)
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Published on: January 7, 2015
J A Pfister1, K E Panter, G D Manners
1USDA-ARS Poisonous Plant Research Laboratory, Logan, UT 84321.
Abstract:
We determined the po toxicity of tall larkspur (Delphinium barbeyi) of known alkaloid composition to cattle. We calculated the effective dose at which the alkaloids methyllycaconitine and 14-deacetylnudicauline, collectively termed total toxic alkaloid, caused collapse and sternal recumbency. The effective dose of total toxic alkaloid that produced sternal recumbency in steers was 11.2 mg/kg bw. Based on this dose, we hypothesize that the LD50 for a po dose of total toxic alkaloids in cattle will be 25 to 40 mg/kg bw.
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