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Pro and anticonvulsant effects of xylazine on convulsion models in rodents
H de S Spinosa1, S L Gorniak, J Palermo-Neto
1Department of Pathology, Faculty of Veterinary Medicine and Zootechny, University of Sao Paulo, Brazil.
Veterinary and Human Toxicology
|February 1, 1994
Abstract:
Pretreatment of mice with 30 mg xylazine/kg ip protected against convulsions induced by amphetamine, but it intensified pentylenetetrazole- and strychnine-induced seizures. Xylazine pretreatment also protected rats against electroshock-induced convulsions. These findings support a noradrenergic mechanism being involved in the proconvulsant and/or anticonvulsant effects of xylazine.