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[Quantitative structure-hypoglycemic activity relationships of some thiazolidine and imidazolidine-2,4-diones]
J G de Lima1, S L Galdino, I da R Pitta
1Département d'Antibiotiques, Université Fédérale de Pernambuco, Cidade Universitaria, Récife, PE, Brésil.
Annales Pharmaceutiques Francaises
|January 1, 1993
Abstract:
Quantitative structure-activity relationships are described for twenty six title compounds. Five compounds exhibit a significant hypoglycemic activity like insulin used as standard. The aim of the present paper is to investigate the contribution of the different substituents in the biological activity. The application of Fujita-Ban and Hansch models has shown that lipophilic and electronic parameters seem to be the best explanation of variance of biological data.