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HLA-DP does not contribute towards susceptibility to systemic lupus erythematosus
E J Davies1, C J Hutchings, M C Hillarby
1University of Manchester, Rheumatic Diseases Centre, Hope Hospital, Salford, United Kingdom.
Objectives:
To determine whether HLA-DP genes are involved in determining susceptibility to systemic lupus erythematosus (SLE).
Methods:
HLA-DPA1 and DPB1 genes were amplified by PCR of DNA samples from a panel of patients with SLE and normal controls. Amplified DNA was blotted on to nylon filters and probed with sequence-specific oligonucleotide (SSO) probes.
Results:
No DPA1 or DPB1 allele was significantly associated with SLE, or with any immunological or clinical subset of SLE. Evidence was found for only limited linkage disequilibrium between HLA-DP and HLA-DQ/DR variants, and none between HLA-DP and the TAP2 gene.
Conclusions:
These data indicate that HLA-DP genes do not contribute towards determining susceptibility to SLE.