[Morphology of granulomatous inflammation in pseudotuberculosis]

The study of pathology in pseudotuberculosis has showed that clinical and morphological nature of the disease is related to granulomatous inflammation in organs and tissues. The authors have established that a relapsing course of this infection may be due to pronounced specific sensitization of the body when granulomas appear in large numbers. Morphogenesis of acute granulomatous inflammation in pseudotuberculosis reflects a consecutive involvement of cellular reactions of the immediate and delayed hypersensitivity. In the authors' opinion pseudotuberculosis granulomas may be assigned to immune hypersensitive granulomas of mixed type according to the classification suggested by A. I. Strukov and O. Ya. Kaufman. The data obtained allow a hypothesis that granulomas tending to cause a purulent liquefaction and necrosis, like pseudo-tuberculous granulomas, could be considered as a morphological sign of granulocytic-macrophagal immune deficiency.