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Effect of polyurethane surface chemistry on its lipid sorption behavior
A Takahara1, K Takahashi, T Kajiyama
1Department of Chemical Science & Technology, Faculty of Engineering, Kyushu University, Fukuoka, Japan.
Journal of Biomaterials Science. Polymer Edition
|January 1, 1993
Summary
Segmented polyurethanes (SPUs) exhibit surface reorganization in response to environmental changes. Hydrophilic SPUs sorbed more lipids, with sorption occurring through both adsorption and absorption.
Area of Science:
- Polymer Science
- Materials Science
- Surface Chemistry
Background:
- Segmented polyurethanes (SPUs) are versatile polymers with tunable properties.
- Understanding the interplay between SPU surface properties and their interaction with biological molecules like lipids is crucial for various applications.
- The influence of different polyol soft segments on SPU behavior requires detailed investigation.
Purpose of the Study:
- To investigate the relationships among surface properties, bulk characteristics, and lipid sorption behaviors of SPUs.
- To analyze the surface chemical structure and reorganization of SPUs in different environments.
- To study the adsorption and absorption of lipids onto SPUs and the competitive sorption of phospholipid and cholesterol.
Main Methods:
- Synthesis of SPUs with varying polyol soft segments: poly(ethylene oxide) (PEO), poly(tetramethylene oxide) (PTMO), and poly(dimethylsiloxane) (PDMS).
- Surface analysis using X-ray photoelectron spectroscopy (XPS) and dynamic contact angle measurements.
- Lipid sorption analysis using infrared spectroscopy.
Main Results:
- SPU surfaces reorganize to minimize interfacial free energy upon transition from air to water.
- Lipid sorption involves both adsorption and absorption into the SPU bulk.
- SPUs with hydrophilic PEO sorbed significantly more phospholipid than hydrophobic PTMO and PDMS based SPUs.
- Increased surface hydrophobicity of SPUs led to a higher ratio of sorbed cholesterol to phospholipid.
Conclusions:
- The choice of polyol soft segment critically influences SPU surface behavior and lipid sorption.
- SPU surface properties are dynamic and adapt to environmental changes, affecting lipid interactions.
- Hydrophilicity/hydrophobicity of SPUs dictates the extent and type of lipid sorption, with implications for biomaterial design.