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Cerebro-spinal fluid cytomorphology in tuberculous meningitis--a preliminary report
P C Jacob1, U Khanduri, S Prabhakar
1Department of Neurological Sciences, Christian Medical College & Hospital Vellore, Tamil Nadu, India.
Abstract:
The morphology of cells in centrifuged cerebrospinal fluid (C.S.F.) of 25 patients with tuberculous meningitis (T.B.M.) in different stages of the illness is presented. Blood brain barrier studies were also done in 6 patients. Maximum variability of cells in the initial stages of the illness and persistence of polymorphs in the later stages of the illness is noted. No correlation was established between cerebrospinal fluid cytomorphology and complications of the illness.
Insights
Cellular changes in cerebrospinal fluid (CSF) of tuberculous meningitis (TBM) patients vary by illness stage. Polymorphs persist in later TBM stages, but CSF cell morphology doesn't correlate with complications.
Area of Science:
- Neurology
- Infectious Diseases
- Cellular Biology
Background:
- Tuberculous meningitis (TBM) is a severe central nervous system infection.
- Cerebrospinal fluid (CSF) analysis is crucial for diagnosing TBM.
- Understanding cellular changes in CSF aids in TBM staging and management.
Purpose of the Study:
- To analyze the cytomorphology of cells in CSF from TBM patients.
- To investigate the relationship between CSF cell morphology and TBM stages.
- To explore potential correlations between CSF cytomorphology and TBM complications.
Main Methods:
- Collected and centrifuged CSF samples from 25 TBM patients across different illness stages.
- Examined the morphology of cells present in the CSF.
- Conducted blood-brain barrier studies in 6 TBM patients.
Main Results:
- Observed significant cellular variability in the early stages of TBM.
- Noted the persistence of polymorphonuclear leukocytes (polymorphs) in later TBM stages.
- Found no established correlation between CSF cytomorphology and TBM complications.
Conclusions:
- CSF cell morphology in TBM exhibits distinct patterns related to disease progression.
- Polymorph persistence in later stages may indicate ongoing inflammation.
- Current cytomorphological analysis of CSF does not predict TBM complications.