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[Calcitonin gene-related peptide (CGRP): a vasodilator neuropeptide with many potential applications]
1Service de Médecine Interne, CHRU, Hôpital de Hautepierre, Strasbourg, France.
Pathologie-Biologie
|December 1, 1993
Abstract:
CGRP (calcitonin gene-related peptide) is a potent vasodilator neuropeptide which acts on peri-arteriolar neurones and is implicated in the pathogenesis of numerous cardiovascular diseases. The synthesis of CGRP antagonists should be useful for the treatment of Raynaud's disease as well as migraine. There exists an homology between the structures of CGRP and pancreatic amylin and therefore an eventual role of CGRP in type II diabetes pathophysiology is currently being studied.