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Published on: May 22, 2018
[Cardiac manifestations of pheochromocytoma]
1Service de médecine interne et nutrition, hôpital de Hautepierre, CHU de Strasbourg, avenue Molière, 67000 Strasbourg, France. florina.luca@chru-strasbourg.fr
Insights
Pheochromocytoma, a rare cause of secondary hypertension, can present with diverse cardiovascular symptoms like arrhythmias and cardiomyopathy. Recognizing these cardiac signs is crucial for early pheochromocytoma detection and management.
Area of Science:
- Endocrinology
- Cardiology
Context:
- Pheochromocytoma is a rare neuroendocrine tumor causing secondary hypertension.
- Cardiovascular manifestations are common but often overlooked presentations of pheochromocytoma.
Purpose:
- To highlight the diverse cardiac presentations of pheochromocytoma.
- To emphasize the importance of considering pheochromocytoma in patients with unexplained cardiac conditions.
Summary:
- Pheochromocytoma can manifest with various cardiovascular symptoms, including arrhythmias, cardiomyopathy, acute coronary syndrome, and cardiogenic shock.
- A specific presentation includes reversible left ventricular apical dyskinesia, resembling Tako-Tsubo cardiomyopathy.
- These cardiac issues are attributed to the toxic effects of elevated catecholamine levels.
Impact:
- Early recognition of cardiac symptoms can lead to prompt diagnosis of pheochromocytoma.
- Increased awareness among clinicians may improve patient outcomes by facilitating timely intervention.
- Understanding catecholamine-induced cardiotoxicity is vital for managing pheochromocytoma patients.
Abstract:
Pheochromocytoma is a rare cause of secondary hypertension which may have protean clinical presentations. Noteworthy, it may be revealed or complicated by cardiovascular symptoms such as arrythmia, cardiomyopathy, acute coronary syndrome and cardiogenic shock. These cardiac manifestations of pheochromocytoma may delay diagnosis and must be known in order to provide the best chance at early detection. In some cases pheochromocytoma may be associated to a large apical dyskinesia of the left ventricule apex, tako-tsubo-like which is a reversible acute myocardiopathy. These acute cardiologic manifestations appear to be induced by a toxic effect of elevated catecholamine levels.
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