A review of axonal transport of metals

Neurons have efficient mechanisms for the transport of organelles and chemical substances in axons to the nerve terminals and back to the cell bodies. Enzymes involved in transmitter synthesis, peptide transmitters and their precursors are examples of macromolecules that are transported down the axon, anterogradely. For final degradation and possible reuse, many constituents are transported back to the cell body, retrogradely. Retrograde transport is also a pathway by which certain toxins may bypass the blood-brain barrier and accumulate in neurons. In recent years, it has been shown that certain metals may accumulate in neurons following retrograde transport. The metals for which retrograde transport has been demonstrated include lead, cadmium and mercury. In this article recent findings regarding axonal transport of metals are reviewed. The putative mechanisms involved in the uptake of metals into the nerve terminal and the fate of metals in the cell body are outlined. Axonal transport of metals as a possible etiological factor in diseases of the human nervous system is discussed.