[Activity of proteinases and alpha-1-proteinase inhibitor under cold stress in rats]

Proteinase and alpha-1-proteinase inhibitor (alpha-1-PI) activity has been investigated in the dynamic of the cold influence in rats. A rise of proteinase activity against a compensatory drop of alpha-1-PI level two hours later their action was observed. Proteolysis activation stimulated the alpha-1-PI synthesis or its release in the blood circulation. A new wave of proteolysis occurs in response to the alpha-1-PI increase. This tight correlation between proteinase and alpha-1-PI activity changes testifies that reactions of organic proteolysis are very significant in the stress response stimulation under the cold influence.