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Capturing host plasmin(ogen): a common mechanism for invasive pathogens?

R Lottenberg1, D Minning-Wenz, M D Boyle

  • 1Dept of Medicine, University of Florida College of Medicine, Gainesville 32610-0277.

Trends in Microbiology
|January 1, 1994
PubMed
Summary

Pathogenic bacteria utilize plasminogen activators to bind plasmin, protecting it from inhibition. This cell-surface plasmin aids bacterial invasion through host tissues.

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Area of Science:

  • Biochemistry
  • Microbiology
  • Pathogenesis

Background:

  • Plasmin is a key enzyme in fibrinolysis and extracellular matrix degradation.
  • Pathogenic bacteria often employ strategies to evade host defenses and invade tissues.
  • Bacterial interactions with host enzymes like plasmin are crucial for understanding infection dynamics.

Purpose of the Study:

  • To investigate the role of bacterial plasminogen activators in pathogenesis.
  • To explore how bacteria bind and utilize plasmin for their benefit.
  • To elucidate the mechanism by which cell-surface plasmin facilitates bacterial tissue invasion.

Main Methods:

  • Analysis of bacterial enzymes involved in plasminogen activation.
  • Characterization of bacterial surface receptors for plasmin(ogen).

Related Experiment Videos

  • In vitro and in vivo models to assess bacterial motility and tissue penetration.

    • Main Results:

    • Several pathogenic bacteria produce enzymes that activate plasminogen.
    • These bacteria efficiently bind plasmin(ogen) to their surface.
    • Bound plasmin is protected from natural inhibitors in the host.
    • Cell-surface plasmin enhances bacterial dissemination through tissue barriers.

    Conclusions:

    • Bacterial acquisition and surface localization of plasmin is a significant virulence factor.
    • This mechanism allows bacteria to degrade host tissues and facilitate invasion.
    • Targeting bacterial plasmin interactions could offer novel therapeutic strategies against infections.