Acute renal failure occurring in scleroderma treated with cyclosporin A: a report of three cases

Cyclosporin A, which is a nephrotoxic agent, has been a mainstay antirejection drug in heart, kidney and lung transplant programmes for about 10 yr. Renal transplant physicians have become adept in balancing its powerful immunosuppressive effects with its undoubted potential nephrotoxicity. Here we report three of eight systemic sclerosis (SSc) patients treated with cyclosporin A who developed acute renal failure. Consideration is given to the evidence of benefit from this agent in SSc and to the management of acute hypertensive renal failure in this disease.