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Updated: Jul 15, 2026

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
Published on: July 14, 2021
Left ventricular remodeling in valvular aortic stenosis. Echocardiographic and clinical changes in two patients
P Faggiano1, C Rusconi, G Ghizzoni
1Division of Cardiology, S. Orsola-Fatebenefratelli Hospital, Brescia, Italy.
Abstract:
Left ventricular (LV) response to chronic pressure overload of aortic stenosis (AS) is usually characterized by an increase of wall thickness without cavity enlargement ("concentric hypertrophy"). During follow-up, two patients with AS developed relevant structural and functional changes of the left ventricle, ie, progressive LV dilatation, wall thinning, and reduction of systolic performance. At the same time, the patients had clinical symptoms of congestive heart failure. The pathophysiologic relevance of this form of LV remodeling in AS is discussed.
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