Meperidine need not be proscribed during sphincter of Oddi manometry

Related Experiment Video

Updated: Aug 19, 2026

Gastrointestinal Motility Monitor (GIMM)
08:15

Gastrointestinal Motility Monitor (GIMM)

Published on: December 1, 2010

G H Elta1, J L Barnett

  • 1Department of Internal Medicine, University of Michigan, Ann Arbor, 48109-0362.

Gastrointestinal Endoscopy
|January 1, 1994
PubMed

Insights

Meperidine did not alter baseline sphincter of Oddi pressure during manometry. However, it increased phasic contractions, suggesting it may improve patient tolerance and success rates for this diagnostic procedure.

Area of Science:

  • Gastroenterology
  • Gastrointestinal Endoscopy
  • Clinical Pharmacology

Background:

  • Sphincter of Oddi manometry is used to diagnose sphincter of Oddi dysfunction.
  • Narcotics, including meperidine, are typically avoided due to concerns of causing sphincter of Oddi spasm.
  • The effect of meperidine on sphincter manometry parameters requires further investigation.

Purpose of the Study:

  • To prospectively evaluate the impact of intravenous meperidine on sphincter of Oddi manometry.
  • To determine if meperidine affects baseline sphincter pressure or phasic contractions.

Main Methods:

  • Prospective study involving 18 patients undergoing manometry for suspected sphincter dysfunction.
  • Diagnostic manometry performed with intravenous diazepam sedation.
  • Meperidine (1 mg/kg IV) administered, followed by repeat manometry after 5 minutes.

Main Results:

  • No significant change in baseline sphincter of Oddi pressure before and after meperidine administration.
  • A statistically significant increase in the frequency of phasic contractions post-meperidine (p = 0.001).
  • Key diagnostic criterion (baseline pressure) remained unaffected.

Conclusions:

  • Meperidine does not alter baseline sphincter of Oddi pressure, a critical diagnostic metric.
  • The increase in phasic contractions suggests meperidine can be safely used for analgesia.
  • Meperidine may enhance patient tolerance and procedural success rates in sphincter of Oddi manometry.

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