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Basal Lamina are the Specialized Form of ECM

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Cell Population Analyses During Skin Carcinogenesis
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Published on: August 21, 2013

Basal cell carcinoma on the lower extremity

K C Carlson1, S M Connolly, R K Winkelmann

  • 1Department of Dermatology, Mayo Clinic, Rochester, Minnesota.

The Journal of Dermatologic Surgery and Oncology
|April 1, 1994
PubMed
Summary

Basal cell carcinomas (BCCs) on the leg are uncommon, affecting 21 patients between 1987-1990. Most patients had fair skin and significant sun exposure, with lesions typically on the anterior lower leg.

Area of Science:

  • Dermatology
  • Oncology

Background:

  • Basal cell carcinoma (BCC) is the most common type of skin cancer.
  • BCCs typically occur on sun-exposed areas of the body.
  • Lesions on the leg are considered uncommon, necessitating further investigation into their unique characteristics.

Purpose of the Study:

  • To investigate the clinical and epidemiological characteristics of basal cell carcinomas located on the leg.
  • To identify risk factors and common presentations of leg BCCs.
  • To evaluate treatment outcomes for leg BCCs.

Main Methods:

  • Retrospective chart review of 648 patients diagnosed with BCC between 1987 and 1990.
  • Analysis of patient demographics, skin type, geographic residence, sun exposure habits, lesion location, clinical recognition, histological subtype, and treatment modality.

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  • Statistical analysis to identify significant associations.

    • Main Results:

    • Twenty-one out of 648 patients (3.2%) had BCCs on the leg.
    • The female-to-male ratio was 1.6:1.
    • The majority of patients had Fitzpatrick skin types I or II and a history of extensive recreational sun exposure, particularly activities involving leg exposure.
    • Lesions were most frequently located on the anterior lower leg, clinically recognized, and histologically classified as superficial BCC.
    • Treatment involved electrodesiccation and curettage or surgical excision.

    Conclusions:

    • Basal cell carcinomas on the leg, though uncommon, share some characteristics with BCCs on other body sites, such as association with fair skin and sun exposure.
    • The anterior lower leg appears to be a common site for leg BCCs.
    • Superficial BCC is the predominant histological subtype.
    • Standard treatment modalities like electrodesiccation and curettage or excision are effective.