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Antiphospholipid syndrome in scleroderma

R Whittaker1, A Barnett, P Ryan

  • 1Department of Medicine, Alfred Hospital, Melbourne, Australia.

The Journal of Rheumatology
|September 1, 1993
PubMed
Summary
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Scleroderma and antiphospholipid syndrome (APS) have rarely been linked. This case report details the first patient with scleroderma and a "full house" diagnosis for APS, highlighting potential vasculopathy.

Area of Science:

  • Rheumatology
  • Immunology
  • Vascular Medicine

Background:

  • Scleroderma is a connective tissue disease with limited reported associations with antiphospholipid syndrome (APS).
  • Previous literature noted only large vessel arterial thrombosis in scleroderma patients with antiphospholipid antibodies.

Observation:

  • This report presents the first case of a patient diagnosed with both scleroderma and a "full house" antiphospholipid syndrome.
  • The patient exhibited a comprehensive serological profile indicative of APS.

Findings:

  • The co-occurrence of scleroderma and a "full house" APS is described.
  • This presentation suggests a potential link between these conditions beyond previously observed manifestations.

Implications:

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  • Early clinical suspicion and prompt investigation are crucial for diagnosing this rare combination.
  • Timely treatment may be vital in mitigating the progression of vasculopathy associated with this syndrome.