Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Voice changes in acromegaly

R G Williams1, S H Richards, R G Mills

  • 1Department of Otolaryngology, University Hospital of Wales, United Kingdom.

The Laryngoscope
|April 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Doctor's Rough Experience with the "Law".

Daniel's Texas medical journal·2023
Same author

Letter from Dr. R. G. Williams; Sweating Feat.

Daniel's Texas medical journal·2023
Same author

A Long Cord.

Daniel's Texas medical journal·2023
Same author

Sympathetic Vomiting of Pregnancy: Two Cases.

Daniel's Texas medical journal·2023
Same author

A study protocol for a double-blind randomised placebo-controlled trial evaluating the efficacy of carrageenan nasal and throat spray for COVID-19 prophylaxis-ICE-COVID.

Trials·2022
Same author

Transcranial focused ultrasound, pulsed at 40 Hz, activates microglia acutely and reduces Aβ load chronically, as demonstrated in vivo.

Brain stimulation·2020
Same journal

Orticochea Flap for Reconstruction of Large Scalp Defects: Outcomes and Technique.

The Laryngoscope·2026
Same journal

Rising Pediatric Button Battery Injuries Despite Safety Efforts: An Analysis of National Injury Data.

The Laryngoscope·2026
Same journal

Laryngeal Nerve Protection Devices in Thyroid Surgery: A Systematic Review and Evidence Synthesis.

The Laryngoscope·2026
Same journal

Practice Patterns for the Management of Pediatric oSDB: What Is the Current National Landscape?

The Laryngoscope·2026
Same journal

Vocal Fold Opening Position Impacts Bowing Measures in Age-Related Vocal Atrophy.

The Laryngoscope·2026
Same journal

Association Between the Modified Frailty Index and Short-Term Total Thyroidectomy Complications.

The Laryngoscope·2026
See all related articles

Patients with acromegaly have a lower fundamental frequency due to vocal cord changes. This vocal change is reversible, with normal fundamental frequency returning rapidly within two weeks after pituitary adenoma surgery.

Area of Science:

  • Otolaryngology
  • Endocrinology
  • Speech Science

Background:

  • Acromegaly, a condition caused by excess growth hormone, can affect various bodily tissues, including the vocal cords.
  • Changes in vocal cord mass and elasticity may influence voice characteristics, specifically fundamental frequency.

Purpose of the Study:

  • To investigate the impact of pituitary adenomas, particularly acromegaly, on vocal fundamental frequency.
  • To assess the reversibility of voice changes after surgical treatment of pituitary adenomas.

Main Methods:

  • Measured fundamental frequency in 14 patients (8 with acromegaly, 3 prolactinoma, 3 nonfunctioning adenomas) undergoing hypophysectomy.
  • Compared patient fundamental frequency to 22 healthy volunteers.
  • Measured external laryngeal size and correlated it with fundamental frequency in volunteers.

Related Experiment Videos

Main Results:

  • Patients with acromegaly exhibited a significantly lower mean fundamental frequency compared to other hypophysectomy patients and healthy volunteers.
  • A relationship between external laryngeal size and mean fundamental frequency was observed in healthy volunteers.
  • Post-surgery, acromegalic patients showed a rapid increase in fundamental frequency to normal levels within two weeks.

Conclusions:

  • Acromegaly is associated with a reversible lowering of fundamental frequency, likely due to altered vocal cord properties.
  • Surgical removal of pituitary adenomas in acromegalic patients leads to a prompt restoration of normal vocal fundamental frequency.