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Mesial temporal cortex hypoperfusion is associated with depression in subcortical stroke

M G Grasso1, P Pantano, M Ricci

  • 1IRCCS S. Lucia Rehabilitation Center of Rome, Italy.

Stroke
|May 1, 1994
PubMed
Summary

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Patients with depression after subcortical stroke show reduced cerebral blood flow in the affected temporal lobe. This hypoperfusion correlates with depression severity, suggesting limbic system involvement.

Area of Science:

  • Neuroscience
  • Neurology
  • Psychiatry

Background:

  • Subcortical stroke can lead to secondary depression.
  • Understanding the neurobiological underpinnings of post-stroke depression is crucial.

Purpose of the Study:

  • To investigate local cerebral blood flow (CBF) changes in patients with depression following a subcortical stroke.
  • To identify specific brain regions affected by hypoperfusion in this patient group.

Main Methods:

  • 15 patients with single subcortical lesions underwent clinical and neuropsychological assessments.
  • Depression was evaluated using DSM-III-R criteria and standardized scales (Hamilton, Zung, Beck).
  • Single-photon emission-computed tomography (SPECT) with 99mTc HMPAO was used to measure CBF.

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Main Results:

  • Cortical regions ipsilateral to subcortical lesions exhibited significantly lower perfusion compared to contralateral areas.
  • Depressed patients showed significantly reduced CBF in the mesial temporal cortex of the affected hemisphere compared to non-depressed patients.
  • CBF in the affected mesial temporal cortex strongly correlated with depression severity.

Conclusions:

  • Hypoperfusion in the temporal lobe may indicate limbic system dysfunction.
  • The mesial temporal cortex appears critical for the development of depressive symptoms after subcortical stroke.