Related Experiment Video
Updated: Jul 28, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Potential glucose sensor for perioperative blood glucose control in diabetes mellitus
K R Greenough1, A W Skillen, C J McNeil
1Department of Clinical Biochemistry, Medical School, University of Newcastle upon Tyne, UK.
Abstract:
A glucose sensor intended for future use in diabetic patients undergoing major surgery is described. It involves glucose oxidase immobilised at a platinised activated carbon electrode (PACE). The sensor gave a nonoxygen dependent amperometric response in whole undiluted blood and did not require the use of electron mediators. In vitro studies in protein containing buffer using a flow cell indicated current densities of approximately 160 nA mm-2 mM-1 and a linear response over the range 0-20 mM. The operational stability of the sensor was at least 49 h in continuous use. In addition the sensor had a 90-99% response time of 1 min when used at a flow rate of 3 ml min-1 and showed a temperature dependence of 2.4% C-1. The results reported suggest significant advantages of this approach, for future use as a perioperative intra-vascular sensor for diabetic subjects, over previously reported glucose sensors.
Related Concept Videos
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...
Diabetes Mellitus: Type 2 and Gestational
Oral Hypoglycemic Agents: Glinides
Hypoglycemia and Glucagon
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Hyperglycemia

