[Immunohistochemical study and evaluation of histogenesis of cardiac myxoma]

In this paper are presented the results of immunohistochemical study of 52 cardiac myxomas, including 2 with glandular structures, and the histogenesis of cardiac myxoma is discussed. Immunohistochemical studies revealed that in all these cases, myxoma cells were positive for vimentin and negative for factor VIII, desmin and actin. In 5 cases, myxoma cells were positive for S-100 protein. The 2 cases with glandular structure were positive for CEA, EMA and Cytokeratin. Histochemical staining showed that PAS AB (pH 1.0), PAS AB (pH 2.5) and HID AB were positive with the glandular elements. The results suggest that cardiac myxomas may be derived from "embryonal rests" and that the glandular structure may originate from entrapped primitive gut rests.