[Cytogenetic study in disorders of human reproduction]

We reviewed 1347 cytogenetic studies performed in a period of eight years to analyze chromosomal translocations and their relation with reproductive failure. Twenty nine index cases were detected representing a global incidence of 2.2% thirteen (45%) were balanced reciprocal translocations between autosomes, thirteen (45%) were robertsonian translocations and three (10%) were X; autosomal translocations. The most frequent indication for the study were, for each group, respectively, recurrent abortion, a child with congenital malformations and ovarian dysfunction. Our results are compared with those of other authors and the mechanisms and figure risks for unbalanced offspring are discussed.