Related Experiment Videos
P 100 latency of the visual evoked response in multiple sclerosis compared with normative data
1Neurologische Klinik, Ev. und Johanniter-Krankenanstalten Duisburg-Nord/Oberhausen, F.R.G.
The International Journal of Neuroscience
|December 1, 1993
Summary
Pattern-reversal visual evoked response P100 latency indicates visual system involvement in all definite multiple sclerosis patients. This occurs even when P100 latency values appear within normal ranges, suggesting subclinical changes.
Area of Science:
- Neuroscience
- Ophthalmology
- Neurology
Background:
- Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system.
- Visual pathway involvement is common in MS, often manifesting as optic neuritis.
- Subtle or subclinical visual system changes may precede overt neurological symptoms.
Purpose of the Study:
- To investigate visual system involvement in definite multiple sclerosis (MS) using pattern-reversal visual evoked response (P-VEP).
- To determine if P-VEP abnormalities are present even when P100 latency falls within normal limits.
- To explore the diagnostic implications for suspected MS cases.
Main Methods:
- Compared P100 latency of pattern-reversal visual evoked responses (P-VEPs) in 65 definite MS patients.
- Utilized normative data from 65 healthy control subjects for comparison.
- Performed distribution analyses to assess P-VEP latency patterns.
Main Results:
- All patients with definite MS demonstrated evidence of visual system involvement.
- This involvement was detected despite some patients exhibiting P100 latencies within the normal range.
- Distribution analyses revealed subtle abnormalities not apparent with standard latency cutoffs.
Conclusions:
- Pattern-reversal VEPs are sensitive indicators of visual system involvement in definite MS.
- Subclinical visual pathway dysfunction is a consistent finding in definite MS.
- These findings support the use of P-VEPs in diagnosing MS, particularly in early or suspected cases.