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Experimental salivary mucoceles in cat. A histochemical study
Journal of Oral Pathology
|December 1, 1975
Summary
Ductal ligation in cats frequently causes sublingual gland mucoceles. Macrophages and fibroblasts attempt to manage mucus buildup, but large extravasations can lead to persistent mucocele formation.
Area of Science:
- Veterinary Medicine
- Oral Pathology
- Salivary Gland Biology
Background:
- Mucoceles are common in animals, often resulting from trauma or ductal obstruction.
- The sublingual gland's role in mucocele formation requires further elucidation.
Purpose of the Study:
- To investigate mucocele formation in feline sublingual glands following ductal ligation.
- To characterize the cellular and tissue reactions to extravasated mucus.
Main Methods:
- Surgical ligation of the sublingual gland duct in cats.
- Macroscopic and histopathological evaluation of gland tissues at various time points.
- Enzyme-histochemical analysis to identify cellular components and mucus characteristics.
Main Results:
- Ductal ligation induced mucocele formation in a high percentage of cats.
- Extravasated mucus was observed up to 20 days post-ligation, with mucoceles persisting in some cases up to 365 days.
- Enzyme-histochemistry revealed macrophage migration and fibroblastic reactions to extravasated mucus.
Conclusions:
- The study demonstrates a high incidence of mucocele formation in cats after sublingual gland duct ligation.
- The host's inflammatory response, involving macrophages and fibroblasts, plays a crucial role in managing extravasated mucus.
- An imbalance between mucus extravasation and removal can lead to the development and persistence of mucoceles.