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The magnesium loading test: reference values in healthy subjects

L Gullestad1, K Midtvedt, L O Dolva

  • 1Department of Medicine, Baerum Hospital, Oslo, Norway.

Scandinavian Journal of Clinical and Laboratory Investigation
|February 1, 1994
PubMed
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The magnesium loading test helps diagnose magnesium deficiency. This study established a wide reference range for magnesium retention in healthy adults, showing good test reproducibility.

Area of Science:

  • Clinical Biochemistry
  • Renal Physiology

Background:

  • Magnesium deficiency diagnosis relies on tests like the magnesium loading test.
  • Establishing a reliable reference range is crucial for accurate clinical interpretation.

Purpose of the Study:

  • To determine the reference range for magnesium retention in healthy adults.
  • To assess the reproducibility of the magnesium loading test.

Main Methods:

  • 88 healthy adults received a 30 mmol intravenous magnesium infusion over 8 hours.
  • Urine was collected for 24 hours to measure magnesium excretion.
  • 23 subjects repeated the test to assess reproducibility.

Main Results:

  • The mean magnesium retention was 6.3 +/- 10.3%, with a wide reference range (-19.5% to 27.5%).

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  • No significant differences were found between sexes or age groups.
  • The test demonstrated fair reproducibility (95% CI: -1.6-5.5%) and 24-hour urine collection was sufficient.

    • Conclusions:

    • The 8-hour magnesium loading test with 24-hour urine collection is reproducible and suitable for clinical use.
    • A wide normal range for magnesium retention was established.
    • Factors like ethanol and exercise can affect magnesium excretion variability.