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Pathological stage I endometrial carcinoma: the role for adjuvant radiotherapy
M Barhum1, M Stein, E Ronsenblatt
1Northern Israel Oncology Center, Rambam Medical Center, Haifa.
Background:
In order to assess the efficacy of adjuvant radiotherapy in the treatment of pathological stage I endometrial carcinoma, we performed a retrospective analysis of 158 patients with this diagnosis who after surgery were either treated with radiation therapy or only followed from January 1980 through December 1987.
Methods:
Patients were divided into two prognostic categories, high and low risk, on the basis of three known predictors of survival: histology, differentiation, and depth of myometrial invasion. All patients underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy but only the high risk group received radiotherapy as well.
Results:
After a median follow up time of 59 months the survival rates of the two groups were similar. The 5-year disease-free survival of the surgery alone group was 92% compared to 89% for the postoperative radiotherapy group. Side effects of treatment were minimal.
Conclusions:
Postoperative radiation therapy for high risk pathological stage I endometrial carcinoma is an effective adjuvant therapy and confers an excellent prognosis.