Related Experiment Videos
Strabismus in the Marfan syndrome
N J Izquierdo1, E I Traboulsi, C Enger
1Johns Hopkins Center for Hereditary Eye Diseases, Wilmer Ophthalmological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland.
American Journal of Ophthalmology
|May 15, 1994
Summary
Patients with Marfan syndrome have a higher prevalence of strabismus, including exotropia and esotropia, compared to the general population. Ocular misalignment and amblyopia are common in this genetic disorder.
Area of Science:
- Ophthalmology
- Genetics
- Pediatrics
Background:
- Marfan syndrome is a genetic disorder affecting connective tissue.
- Ocular manifestations are common in Marfan syndrome, but strabismus prevalence is not well-established.
Purpose of the Study:
- To investigate the prevalence of strabismus, refractive errors, and amblyopia in patients with Marfan syndrome.
- To compare the occurrence of strabismus in Marfan syndrome patients to the general population.
Main Methods:
- Retrospective chart review of 573 patients diagnosed with Marfan syndrome.
- Assessment of ocular misalignment (strabismus), refractive errors, and amblyopia.
- Statistical comparison with general population data.
Main Results:
- 19.2% of patients with Marfan syndrome had strabismus.
- Exotropia (11.7%) and esotropia (2.1%) were the most common types of strabismus.
- Strabismus, particularly exotropia, was significantly more prevalent in Marfan syndrome patients than in the general US population.
Conclusions:
- Strabismus is a frequent ocular finding in Marfan syndrome.
- Factors such as ectopia lentis and craniofacial abnormalities may contribute to strabismus development.
- Early detection and management of strabismus are important for patients with Marfan syndrome.