Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intravascular contrast media and thrombin generation

Z Parvez1, H Vik

  • 1Radiology Research Laboratory, VA Medical Center, Hines, IL.

Acta Radiologica (Stockholm, Sweden : 1987)
|March 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sezary syndrome.

Mymensingh medical journal : MMJ·2011
Same author

Contrast media leakage to the cerebrospinal fluid after intravenous injection. Comparison of stroke patients and controls.

Acta radiologica (Stockholm, Sweden : 1987)·1995
Same author

Doxorubicin treatment of rabbit renal VX-2 carcinoma: nephrotoxicity, serum parameters and weight.

Urological research·1995
Same author

Coronary angioplasty using a low osmolar nonionic contrast medium. A retrospective angiographic and clinical evaluation.

Acta radiologica (Stockholm, Sweden : 1987)·1995
Same author

Cerebral thromboembolic complications associated with the use of a nonionic contrast medium in coronary angiography.

Acta radiologica (Stockholm, Sweden : 1987)·1995
Same author

Biochemical and morphological effects of contrast media on the kidney.

Acta radiologica. Supplementum·1995
Same journal

Radiomics based on MRI for preoperative prediction of the tumor budding grade in rectal cancer: a systematic review and meta-analysis.

Acta radiologica (Stockholm, Sweden : 1987)·2026
Same journal

Improved pancreatic imaging with photon-counting CT: a retrospective comparison with conventional CT.

Acta radiologica (Stockholm, Sweden : 1987)·2026
Same journal

The role of ultrasonography in diagnosing cystic adventitial disease.

Acta radiologica (Stockholm, Sweden : 1987)·2026
Same journal

Exploring artificial intelligence in point-of-care and standard breast ultrasound: a paired reader study.

Acta radiologica (Stockholm, Sweden : 1987)·2026
Same journal

Diagnostic performance of contrast-enhanced ultrasound for thyroid nodule characterization: a systematic review and meta-analysis.

Acta radiologica (Stockholm, Sweden : 1987)·2026
Same journal

Dynamic breast magnetic resonance imaging features and pathological correlation of patients diagnosed with breast cancer under the age of 40.

Acta radiologica (Stockholm, Sweden : 1987)·2026
See all related articles

Ionic and nonionic contrast media (CM) were tested for effects on thrombin generation. Neither ionic nor nonionic CM enhanced thrombin generation in vitro, suggesting anticoagulant properties.

Area of Science:

  • Biochemistry
  • Hematology
  • Medical Imaging

Background:

  • Contrast media (CM) are widely used in medical imaging.
  • Understanding the hemostatic effects of CM is crucial for patient safety.
  • Previous research has yielded conflicting results regarding CM's impact on coagulation.

Purpose of the Study:

  • To investigate the in vitro effect of ionic and nonionic contrast media on thrombin generation.
  • To assess the procoagulant activity of nonionic contrast media.

Main Methods:

  • Incubation of nonanticoagulated whole blood with ionic CM (diatrizoate, ioxaglate) and nonionic CM (iohexol, iopamidol) or glucose.
  • Measurement of thrombin generation markers (F1+2, ATM, FpA) using ELISA.
  • Evaluation of procoagulant activity of nonionic CM (iohexol, iopamidol, iopromide) via one-stage plasma recalcification time.

Related Experiment Videos

Main Results:

  • Incubation with ionic and nonionic CM did not enhance thrombin generation compared to glucose control.
  • Plasma recalcification times were not significantly shortened by the tested nonionic CM.
  • Ionic and nonionic CM demonstrated no procoagulant activity in vitro.

Conclusions:

  • Ionic and nonionic contrast media do not enhance thrombin generation in vitro.
  • Nonionic contrast media do not exhibit procoagulant activity.
  • These findings suggest that contrast media possess anticoagulant properties in vitro.