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Late onset mania in Down's syndrome

S A Cooper1, R A Collacott, A Hauck

  • 1Department of Psychiatry of Leicester University, Frith Hospital, England.

Journal of Intellectual Disability Research : JIDR
|February 1, 1994
PubMed
Summary

Manic episodes are rare in Down

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Area of Science:

  • Neurology
  • Psychiatry
  • Genetics

Background:

  • Down's syndrome is a genetic disorder associated with intellectual disability.
  • Bipolar disorder, including manic episodes, is infrequently reported in Down's syndrome.
  • Late-onset psychiatric conditions require careful consideration in this population.

Observation:

  • A case study of an individual with Down's syndrome experiencing a manic episode later in life is presented.
  • The patient presented with symptoms indicative of mania.
  • This was followed by a subsequent depressive episode.

Findings:

  • The case highlights the possibility of late-onset manic episodes in individuals with Down's syndrome.
  • The presentation and course of bipolar disorder may differ in this demographic.
  • The occurrence of both manic and depressive episodes suggests a bipolar disorder spectrum presentation.

Implications:

  • Increased awareness and vigilance for mood disorders in individuals with Down's syndrome are warranted.
  • Further research is needed to understand the prevalence and phenomenology of bipolar disorder in Down's syndrome.
  • This case underscores the importance of comprehensive psychiatric assessment in aging individuals with Down's syndrome.

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