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Updated: Aug 11, 2026
A Model of Chronic Nutrient Infusion in the Rat
Published on: August 14, 2013
[Comparative study of long-term parenteral nutrition with medium-chain and long-chain triglycerides in
A Herrmann1, K W Jauch, S Hailer
1Chirugische Klinik und Poliklinik, Ludwig-Maximilians-Universität München, BRD.
Objective:
To determine the effect of a pure glucose and of different glucose/fat regimens as nonprotein energy source on substrate metabolism, nitrogen balance, lipoprotein pattern and liver enzymes. Long-chain and mixed long-/medium-chain triglyceride emulsions as 10 and 20% solutions were infused.
Design:
Prospective randomized study.
Setting:
General ward of a university hospital.
Patients:
29 patients in five groups after colorectal surgery.
Interventions:
According to Harris-Benedict an amount of 150% of the calculated daily calorie intake was infused. Besides nitrogen balance and routine laboratory tests the lipoprotein pattern was examined.
Results:
No difference was observed in protein balance, while a pathological rise of liver enzymes was mainly seen with glucose 20% and long-chain fat emulsions in a concentration of 10%. Physiological lipoprotein balance could only be achieved with a 20% solution of long-chain and medium-chain emulsions.
Conclusions:
The results demonstrate a fast metabolism of the MCT/LCT 20% solution with physiological lipoprotein pattern and no change in liver enzymes. High-dose glucose infusions and long-chain fat emulsions may cause a fatty degeneration of the liver, and 10% MCT/LCT emulsions may cause a rise of phospholipids and a generation of lipoprotein X.
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