Related Experiment Videos
Blood/air partition coefficient determinations: automation and improvement of the equilibrium partitioning in closed
R L Dills1, W S Ackerlund, D A Kalman
1Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle 98195.
Abstract:
The equilibrium partitioning in closed systems method has been frequently used for determining partition coefficients between liquid and gas phases. We developed several improvements in this method: preparation of test atmospheres with a dynamic solvent vapor generator, automation of gas phase analysis, and estimation of the precision of the partition coefficients using a statistical procedure that did not require pairing of test and reference measurements. Blood/air partition coefficients measured in a blood-bank blood sample for acetone, 1,1,1-trichloroethane, toluene, and styrene were: 309 +/- 2, 5.6 +/- 0.1, 16.2 +/- 0.5 and 49 +/- 2 (geometric mean +/- estimated SE, respectively). Water/air partition coefficients were: 361 +/- 7, 2.9 +/- 0.3, 4.6 +/- 0.5, and 6.9 +/- 0.9 for acetone, 1,1,1-trichloroethane, toluene, and styrene.