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Synthesis and antibacterial activity of new 2-substituted penems. II
1Exploratory Research Laboratories I, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
The Journal of Antibiotics
|March 1, 1994
Abstract:
A series of new penems (4-17), having a bicyclic imidazole moiety as the C-2 substituent, has been synthesized. The antimicrobial activity of these compounds and their susceptibility to renal dehydropeptidase-1 (DHP-1) are elucidated, and their structure-activity relationships are discussed.
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